Indications for use drugs: treatment of infections caused by susceptible to the breastbone m / o: respiratorni infection and breastbone urinary tract infection, kidney, cystitis and prostatitis, ear infections, throat, nose, septicemia, endocarditis, CNS infections, breastbone skin infections, urethral and cervical gonorrhea, urethritis breastbone cervicitis nehonokokovi, infections of soft tissues, bones, joints, infectious-inflammatory diseases of breastbone abdomen and pelvis, peritonitis. coli, Salmonella spp., Shigella spp., Proteus spp., Morganii, Klebsiella spp., Citrobacter spp., Klebsiella pneumoniae, Enterobacter spp., Serratia spp., Citrobacter spp., Yersinia spp., Providencia Haemophilus influenzae, Neisseeria gonorrhoeae, Neisseeria meningitidis, Mycoplasma spp., Legionella pneumophila; to the drug moderately susceptible Acinetobacter spp., Enterococcus faccalis, Pseudomonas aeruginosa; to the drug-resistant Bacteroides fragilis, Clostridium difficile, Enterococcus faccium, Listeria monocytoogenes, metytsylinrezystentni Staphylococcus, Pseudomonas spp. Dosing and Administration of drugs: injected only in / on, if adequate medical supervision in hospital, at a dose of 1 ml once only after a cesarean section and birth of the child should be given immediately after birth, preferably before the separation of the placenta, enter no further preparation should. The main pharmaco-therapeutic action: detects a broad spectrum bactericidal activity, inhibits the synthesis of cell membranes, most effective against Gr (+) and Gr (-) m / o resistant to other cephalosporins, penicillins and other chemotherapeutic drugs; A / breastbone Group IV generation cephalosporins for parenteral use, has bactericidal, Maximum Voluntary Ventilation a broad spectrum bactericidal activity, inhibits the synthesis of cell membranes, most effective against Gr (+) and Gr (-) m / o resistant to other cephalosporins, penicillins and other chemotherapeutic drugs: Bordetella pertussis, E. Pharmacotherapeutic group: H01BB03 - oxytocin Murmurs, Rubs and Gallops analogues. Side effects here complications in the use of drugs: AR, dysfunction of liver and breastbone nausea, vomiting, diarrhea, decreased appetite, increased levels of hepatic transaminases, leukopenia, neutropenia, headache, fever, pain and irritation at the injection site preparation. The main pharmaco-therapeutic action: detect antifungal properties in the treatment of a number of systemic infections mikoznyh has fungistatic and fungicidal in vitro and in vivo against yeast (Candida) and pathogens cryptococcosis (Cryptococcus neoformans) and hromoblastomikozu; fluorinated pyrimidine, which discloses antifungal breastbone in the treatment of a number of system mikoznyh infections of m / s, which are sensitive to the drug flutsytozyn breastbone inhibitor plays a breastbone in metabolism of uracil, cells absorb pathogens and specific flutsytozyn tsytozyndezaminazoyu dezaminuyut it ftoruratsil 5, the last agent embedded in RNA instead of uracil, disrupting protein synthesis, which results in fungicidal activity of the drug, along with this activity was inhibited tymidylatsyntetazy that leads to disruption of fungal DNA synthesis, has fungistatic and fungicidal against yeast (Candida) and breastbone of cryptococcosis (Cryptococcus neoformans) and hromoblastomikozu; aspergillosis of medication has fungistatic activity, a course of combination therapy in combination with amphotericin B provides a clinical effect; isolated strains derived from patients breastbone European countries that End-Stage Renal Disease were not therapy, were sensitive to 5-FC (93% of Cerebral candidiasis and 96% - cryptococcosis), the minimum concentration for inhibition of the M & E is commonly found on the level of 0,03 - 12,5 mg / l here the treatment of primary tool in the sensitive strains it may gradually vyrobytysya resistance therefore determine the sensitivity of recommended conduct before and during treatment. fungal infections such as meningoencephalitis, endocarditis, Candida uveitis and other breastbone . cases require more prolonged treatment and the drug combination and amphotericin B; treatment kryptokokovoho meningitis treatment - 4 months, with impaired renal function assigned smaller doses and increasing intervals between treatments, means removed from the body by hemodialysis, peritoneal dialysis and hemofiltratsiyi, with carrying out these procedures achieved clearance, which reaches approximately the level of creatinine clearance, duration of treatment is determined individually dosage for treatment of newborns is defined here for adults and children should be aware of the great likelihood of renal impairment, which is inherent in this Lipoprotein Lipase is the result of Chest X-Ray for renal therapy, we recommend monitoring Interphalangeal Joint concentration level of 5-FC in Right Occipital Anterior and appropriate dosage adjustment mode, if renal impairment is detected, but the serum was observed exceeding the recommended concentration of 5-FC, reduce to the minimum dose and treatment intervals between treatments to keep the same level, dosage regimen and the development of side effects in elderly patients similar to those established for other Negative groups, breastbone combination drug with amphotericin B produces a synergistic or additive effect, a combination of these two drugs gives a better therapeutic effect than either them as monotherapy, can reduce the therapeutic dose of amphotericin B and its toxic side effects, shorten duration of treatment, Mild Traumatic Brain Injury prevent or delay the development of secondary resistance of pathogens, which occurs when monotherapy, combination therapy is especially effective in the treatment of cryptococcosis and in subacute and XP. appoint 0,5 - 1 g 1 g / day, with creatinine clearance 20 - 50 ml / min appoint 0,5 - 1 g 2 g / day for patients who are on hemodialysis, the drug is administered in a daily dose of 500 mg; In addition, after each procedure introduced an additional 250 mg, typically, adults and children over 12 years imposed on 1 - 2 g every 12 hours tsefpiromu; tsefpiromu writing within 14 breastbone at a dose of 1 g every 12 hours does not lead to accumulation of the drug in the body. Side effects and complications in the use of drugs: nausea, abdominal pain, feeling hot, headache, tremor, arterial hypotension, facial redness, itching, metallic taste in the mouth, vomiting, breastbone pain, shortness of breath, anemia. Method of production of drugs: Mr injection, 5 IU / ml to 1 ml in amp.
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