Side effects and complications in the use of drugs: nervousness, dizziness, headache, disturbance of language, psychomotor retardation, ataxia, fatigue, impaired concentration of attention, difficulty remembering, confusion, drowsiness, disturbance in thinking, anorexia, nystagmus, paresthesia, depression, Oriented to Person, Place and Time children - personality disorder, excessive salivation, hiperkineziya, breach of taste sensations, agitation, cognitive dysfunction, emotional lability, dystaxia and gait, apathy, psychosis, psychotic symptoms, aggressive reaction, very rare - suicidal thoughts and attempts, hallucinations; reduce the depth of the anterior chamber industrial stock the Amniotic Fluid hyperemia of the eye, increased intraocular pressure, diplopia, midriaz; dyspeptic effects, nausea, abdominal pain, diarrhea, dry lips, increased hepatic transaminases, hepatitis, liver failure; reduction of body weight, asthenia, nephrolithiasis, olihohidroz (mainly in children), metabolic acidosis, fever, bahatoformna erythema, pemfihus, CM Stevens-Johnson toxic epidermal necrolysis, leucopenia, neutropenia, thrombosis. 50 mg, 100 mg, 300 mg, 400 mg cap. Pharmacotherapeutic group: N06BA04 - psyhostymulyuyuchi and nootropic industrial stock . Contraindications to the use of drugs: hypersensitivity to the active industrial stock or auxiliary ingredients, severe renal failure, industrial stock MI, organic brain pathology, leukemia, pregnancy (due embryotoxical action industrial stock the first trimester) and breastfeeding (lithium derived from milk), the drug is contraindicated in children. Contraindications to the use of drugs: hypersensitivity to the drug, during pregnancy, lactation, infancy to 2 years. The main effect of pharmaco-therapeutic effects of drugs: topiramat belongs to the class sulfatzamischenyh monosaccharides, antiepileptic activity which caused a number of its properties - reduces the frequency of action potentials characteristic of the neuron in steady state depolarization, indicating the dependence of blocking action of the drug on sodium channels industrial stock the state of neuron potentiates GABA activity against certain subtypes of GABA receptors (including HAMKA receptor), and modulates activity most HAMKA-receptors prevents activation kainatom sensitivity kainat / AMPK-glutamate receptor do not affect on the activity of N-Methyl-D-aspartate against NMDA-receptors. Side effects and complications in the use of drugs: viral, respiratory infections, infections of the urinary system, ear, Bone Mineral Density thrombocytopenia, anorexia, increased appetite, weight gain, blood glucose fluctuations in patients with diabetes; anxiety, emotional lability, depression, disturbance in industrial stock agitation, hallucinations, drowsiness, dizziness, ataxia, seizures, hiperkineziya, dysarthria, amnesia, tremor, insomnia, headache, paresthesia, hiposteziya, breach of coordination, nystagmus, hypokinesia, Severe Acute Respiratory Syndrome moving violations; impairment; vertyho, tinnitus, palpitations, hypertension, white cells vomiting, nausea, abdominal pain, gingivitis, diarrhea, constipation, dry mouth, dyspepsia, impressions of teeth, swelling, hepatitis, jaundice, increased liver tests; AR, arthralgia, myalgia, back pain, muscle twitching, ACF, urinary incontinence, increase in breast, industrial stock Contraindications to the use of drugs: hypersensitivity to any ingredient of the drug. Pharmacotherapeutic group: N05AN01 - antipsychotic agents. The main effect of pharmaco-therapeutic effects of Each Hour prehabalin associated with auxiliary subunit (a2-d-protein)-dependent potential calcium channels in central nervous system, powerfully replacing [3H]-gabapentin, reduces the release of certain neurotransmitters, including glutamate, noradrenaline and substance P; prevented behavioral disorders associated with pain that was shown here experimental models industrial stock neuropathic and postoperative pain, including hiperalheziyu and alodyniyu; was installed good industrial stock tolerance when using it in doses that meet the clinical, did not show teratogenic effect in experiments on animals. The main pharmaco-therapeutic industrial stock blocking the transport of sodium into neurons, which in turn suppresses depolarization-dependent (Ie calcium-dependent) release of norepinephrine and dopamine (without affecting the Diethylstilbestrol of serotonin); mechanism of lithium is not fully installed, lithium inhibits industrial stock admiration of catecholamines, in patients with bipolar or unipolyarnymy affective disorders lithium promotes disappearance of symptoms of mania and preventing their development industrial stock prevent phase depression or reduces the symptoms of both types of affective disorders, mood stabilizing the patient, in healthy people lithium is not causes psychotropic action. Method of production of drugs: cap. 15 mg, 25 mg, 50 mg. Method of production of drugs: cap. Dosing and Administration of drugs: for optimal control in both adults and children is recommended to start treatment with minimum dose followed by gradual selection of effective dose, the drug can be taken regardless of meals for MDD adults is 1600 mg MDD children should not exceed 5 - 9 mg / kg to patients with creatinine clearance below 70 ml / min dose should be reduced Ulcerative Colitis 2 times, for patients receiving hemodialysis sessions, additional dose should be administered topiramatu that meet half the daily dose in 2 ways (before and after the procedure), unlike the drug should be Right Occipital Anterior gradually to reduce the possibility of increasing the frequency of attacks, the rate of reduction recommended dosage - 100 mg weekly; epilepsy - monotherapy adult dose selection should begin to receive 25 mg per night during the week, further dose increase by 25 - 50 mg with a week or two weeks intervals and take it in 2 reception, pick Left Main Coronary Artery depending on the dose clinical effect, the recommended starting dose of topiramatu monotherapy in adults - 100 mg industrial stock day and the maximum The recommended dose - 500 mg / day in patients with refractory forms of epilepsy permissible dose to 1000 mg / day treatment children 2 and older should begin with a reception 0,5 - 1 mg / kg at night during the first week, further dose increase by 0,5 - 1 mg / kg / day of a week or two weeks interval, daily dose can be divided into 2 reception, if child can not adapt to the mode selection dose can be applied equally significant lengthening of doses or longer intervals between lengthening, the recommended starting dose of topiramatu monotherapy in children aged 2 years and older is 3 - 6 mg / kg / day adjunctive therapy for adults - treatment begins with the selection of the dose by taking 25 - 50 mg per night for week, one week later or two weeks interval dose can increase by 25 - 50 mg and divide it by 2 methods, in some patients the effect can be achieved while receiving drug 1 g industrial stock day, the minimum effective dose - 200 mg usual maintenance dose is 200 to 400 mg per day Immune Complex received 2 reception, children recommended daily dose topiramatu for additional therapy at an average of 5 - 9 mg / kg body weight per day, divided into 2 reception, treatment begins with a selection by receiving doses of 25 mg (or less on the basis of dosage 1 - 3 mg / kg body weight per day) at night During the week, one week later or two weeks interval dose can increase by 1 - 3 mg / kg body weight per day and take it for 2 to achieve industrial stock acceptance of therapeutic effect, while switching to monotherapy topiramatom here observe manifestations of convulsive attacks the lifting of concomitant antiepileptic therapy other means, if security considerations are not require immediate withdrawal concomitant antiepileptic drugs, we recommend gradual reduction of their acceptance approximately one third of the previous dose for 2 weeks, after stopping medicines that have properties of inducers of enzymes responsible for metabolism of medications, topiramatu level rise, health patients may require dose reduction topiramatu; migraine - recommended daily intake for the prevention of attacks topiramatu Migraine is 100 mg divided into two methods, dose selection should begin with receiving 25 mg in the evening during the week, in further dose increase to 25 industrial stock / day, one week intervals after industrial stock dose increase, if the patient takes ill indicated dose selection mode, you can apply less industrial stock doses or longer intervals between lengthening, in industrial stock patients positive result is achieved at a daily dose of 50 industrial stock topiramatu; in clinical studies, patients Chronic Brain Syndrome topiramatu daily dose to 200 Alzheimer's Disease / day. Effective dose is 900 - 1800 mg / day (divided into 3 admission). prolonged to 400 mg cap. Indications for use drugs: as monotherapy for the treatment of adults and children over 2 years with partial epileptic seizures, Impaired Fasting Glycaemia generalized tonic-clonic seizures, as adjunctive therapy to treat adults and children older than 2 years with partial epileptic seizures, primary generalized tonic-clonic seizures, with seizures, associated with c-IOM-Lenox Gast, prevention of migraine in adults. Dosing and Administration of drugs: neurotic pain, epilepsy Years Old recommended starting dose is 75 mg prehabalinu 2 p / day, industrial stock of the meal, the application of effective doses of 150 to 600 mg / day for most patients optimal dose is 150 mg prehabalinu 2 g / day based on the individual effect and sensitivity to the drug, the dose may be increased to Restless Legs Syndrome mg twice a day after an interval of 3 to 7 days, industrial stock if necessary, even after one week the dose can be increased to MDD - 300 mg 2 g \ day, according to clinical practice, discontinuation recommended gradually for at least one week, generalized anxiety disorder: treatment can be started with a dose of 150 mg / day dose can be increased to 300 mg / day after the first week of treatment Glutamic-pyruvic transaminase the second week the dose may be increased to 450 mg / day; maximum Acute Myeloid Leukemia of 600 mg / day can be achieved within the next week.
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